The issue of mixing creatine and caffeine has been discussed extensively in both the athletic and scientific communities.
Creatine works on the phosphocreatine and ATP systems while possibly buffering exercise produced hydrogen protons (acid). Caffeine demonstrates a powerful stimulation for the release of epinephrine. Theoretically, could take both these substances can help a person gain more of a performance edge. But the study discovered that maybe they can not cooperate. Even more, it showed that they may interfere with one another.
Studies have shown that extended caffeine use can completely destroy the physical benefits resulted by creatine use. By contrast, a single dose of caffeine immediately before exercise either will not have any effect or even enhance the improvement in strength observed with creatine. Therefore, at least as far as creatine is concerned, chronic caffeine consumption appears to be much more counterproductive than an occasional cup of coffee.
If you are seriously going to get the most from creatine supplement, you’d better try to avoid use of caffeine. Studies show that the equivalent of three cups of coffee per day for as little as three days can completely negate the benefits of creatine in your system. Although an occasional cup of coffee doesn’t seem to do much harm.